Keynote Lecture Series

Michael Levine

1:05:20

Mechanisms of transcriptional precision in the Drosophila embryo

Weizhe Hong

45:48

Larry Katz Lecture

Bob Kingston

56:50

Oligodendroglial metabolism and the support of axonal intergrity

Marie-Anne Felix

42:37

Natural populations of Caenorhabditis and studies on apparent and cryptic phenotypic variation

Philip Ingham

1:05:26

Two decades of sonic hedgehog

John Gurdon

1:02:12

The stabilization of cell differentiation

David Lane

1:46:56

Analysis of the p53 pathway in zebrafish

Steven Henikoff

Mapping genome-wide nucleosome dynamics

Susan Wessler

41:19

The success strategies of transposable elements that rapidly diversify genomes

Maxine Linial

1:09:17

40 Years in Retrovirology, a Reminiscence

Jonathan Stoye

54:19

Germ line retroviruses-good or bad?

John Mellors

1:14:49

Can HIV-1 be eradicated from the individual and the world?

Stefan Lohmander

1:50:48

Osteoarthritis —Understanding a common complex disease

Charles Sherr

46:09

Keynote Lecture

Jennifer Doudna

49:15

Programmable RNA-guided genome defense in bacteria

Adrian Bird

41:42

The dinucleotide CG as a genomic signalling module

Yuh-Nung Jan

29:58

Identification and studies of mechano-transduction channels in Drosophila

Lily Jan

29:45

Recent studies of potassium channels and a novel family of calcium-activated anion channels and cation channels

Lucy Shaprio

53:28

An integrated 3D network controls a bacterial cell cycle

Zhu Chen

52:01

Synergistic targeting therapies against oncoproteins for acute myeloid leukemia

Stephan Baylin

45:02

The era of the cancer epigenome: Dissecting the biological and translational implications

Carlo Croce

47:10

Causes and consequences of microRNA dysregulation in cancer

Retta Beery

35:48

The Beery Family Journey—A sequencing success

Carlo Croce

50:10

MicroRNAs can function as ligands for TLR and regulate the interactions between cancer cells and their microenviroment

Maynard Olson

45:06

Three cautions about personalized medicine

Clifford Tabin

40:36

Gut morphogenesis—From physical forces to localization of stem cells

Eric Schadt

1:02:30

Considering the digital Universe of data to better diagnose and treat patients

Eric Lander

1:02:58

Keynote Lecture

Tom Rapoport

58:44

Mechanisms of protein translocation across membranes

Reinhard Jahn

52:49

Exocytosis in neurons—Interplay between proteins and lipids

Warner Greene

1:11:20

T cell death and chronic inflammation: An unexpected link in HIV infection

Ben Berkhout

1:08:29

HIV RNAAAAAAA

Robert Farese

50:26

The roots of obesity—Mechanisms of lipid synthesis and storage

Hidde Ploegh

58:22

The Logic of Your Immune System

Edmund Rolls

1:05:25

“On the rules of cortical wiring and function, with implications for understanding psychiatric disorders”

Michael Brown

1:18:37

SCAP: Sensor of Membrane Cholesterol

Stefan Hell

1:09:37

Nanoscopy with focused light

Rudolf Jaenisch

1:01:01

Stem cells and pluripotency—Mechanisms of reprogramming and gene targeting in ES cells and mice

Leroy Hood

How systems medicine is changing healthcare

Jan Melom

59:39

Visualizing calcium—Insights into quantal synaptic transmission and cortex glial function

Joel Sussman

47:58

Proteopedia—A scientific 'Wiki' bridging the rift between 3D structure and function of biomacromolecules

Richard A. Young

1:08:44

Super-enhancers and the control of cell identity and disease

Eric Nestler

1:06:24

New insight into the neurobiology of depression

Lior Pachter

46:40

Stories from the Supplement

Hugh Reinhoff

33:07

My daughter's DNA and every little thing about her?

Richard Durbin

50:11

Some thoughts on ever more available sequencing

Michel Nussenzweig

55:25

Harnessing immunity to prevent and treat HIV infection

Ross Hardison

1:01:11

Genomics of hematopoietic gene regulation

Jacob Howard

53:57

How do you get rat research support in world of GWAS and whole genome sequencing in humans?

David Burt

46:02

Avian genomics a decade after the publication of the chicken genome sequence

Ramon Parsons

45:56

Keynote address

Hidehiko Inagaki

1:06

Neuronal mechanism of state control in Drosophila melanogaster

Peter Donnelly

48:29

Genomic Discovery: Mechanisms of Meiotic Recombination

Nancy Moran

45:31

Genomic Erosion in Symbiotic Bacteria

Mary Carrington

1:05:23

The influence of immunogenetic variation on HIV disease

David Moore

47:18

Targeting CAR to Treat and Prevent Liver Cancer

Rui Costa

1:03:28

Generating and shaping novel action repertoires

Stephen Harrison

1:01:15

Membrane dynamics and virus entry—From atomic structures to single-molecule movies

Keiichi Namba

57.11

CryoEM image analysis of macromolecular motor assemblies

Wolfgang Baumeister

55:00

Unveiling the long-held secrets of the 26S proteasome

Loren Looger

Tools for studying neurons, the only important cells in the brain

Gerard Evan

47:31

Targeting cancer’s engines, not its drivers

Arnold Levine

47:28

The evolution of thymic lymphomas in P53 knock-out mice

Fred Winston

44:15

Analysis of the role of Spt6 in controlling transcriptional accuracy in yeast

Toshio Matsumoto

59:35

Progress and perspectives of osteoporosis treatment

Paul Bieniasz

1:11:39

Keynote Speaker

David Haussler

1:33:12

Global exchange of human genetic data for medicine and research

Laurie Zoloth

36:11

Truth and consequences—Reflections on ethical issues in synthetic biology

Christopher Voight

46:23

Pushing the scale of Genetic Engineering

Maiken Nedergaard

1:12:49

The Glymphatic System

Marc Kirschner

1:14:13

How biology optimizes both specificity and efficiency—Single molecule studies of ubiquitylation

Ivan Dikic

54:15

Ubiquitin and Autophagy Networks

Arul Chinnaiyan

1:06:04

The application of integrative sequencing for precision medicine

Gene Robinson

1:06:19

Transcriptional regulation and metabolism: key elements in the evolution and mechanisms of social life in bees

Judith Korb

51:07

Comparative transcriptomics reveals the modular organization of ant phenotypic traits

Laurent Keller

53:40

The influence of genes and social environment on behavior and social organization

Brenda Schulman

53:45

Celebrating the ubiquitin family;diversity of cullin-RING Ubl and Ub ligation mechanisms

George Davey Smith

56:07

Mendelian randomization:Harnessing genocopy/phenocopy to identify modifiable causes of disease

Francis Collins

50:58

From the HGP to Precision Medicine

Susan Ross

56:25

Using mouse genetics to study host-virus interactions

Svante Paabo

The Genetic Legacy of Neanderthals

Frank Slack

48:52

MicroRNAs in aging

Eric Shoubridge

Posttranscriptional regulation of mitochondrial gene expression

Alfred Goldberg

55:06

Regulation of proteasome function in normal and disease states

Alan Rein

1:01:02

Retroviruses; Some Perspectives

Robert Kingston

43:41

Nucleosome compaction as a regulatory mechanism during development

Aviv Regev

1:20:25

Towards a neuron cell atlas

Mingyang Lu

Interrogating the robustness of gene regulatory circuits by RACIPE

Marian Walhout

1:01:26

Gene Regulatory Networks

Marc Vidal

1:27:27

"Edgetics"

Anne Bertolotti

53:04

Maintaining proteasome homeostasis

Christopher Lima

52:16

Ubiquitin-like proteins:From conjugation to recognition

Andrew Clark

54:33

Junk Evolution

Stephen Hughes

1:11:52

Why study integration and reverse transcription

Craig Thompson

1:04:44

Manipulating cell death—The discovery and preclinical development of Bcl-2 inhibitors

Raphael Cohn

52:46

Circuit mechanisms for flexible sensorimotor processing in Drosophila

Michael Karin

59:23

De novo lipogenesis induced by ER stress is essential for hepatic steatosis and its progression to NASH

Elaine R. Mardis

49:51

PERSONALIZED CANCER GENOMICS: IMPACT AND IMPLICATIONS

Maricel Kann

58:12

“A protein-domain approach for the analysis of disease mutations”

Lior Pachter

1:01:34

“Post-procrustean bioinformatics”

Edward Boyden

1:13:29

"Optical tools for analyzing and repairing complex biological systems"

Ellen Rothenberg

1:27:53

"Dissection of the regulatory trajectory for early T-cell lineage commitment"

Svante Paabo

1:06:51

"Using ancient genomes and model systems to study uniquely human phenotypes"

Insoo Hyun

56:21

"3D models of the human brain—What are the ethical concerns and how should they be addressed?"

Geeta Narlikar

50:05

Understanding the biochemical and biophysical basis for genome organization

Steven Henikoff

51:47

Structural epigenomics (precision mapping of the chromatin landscape)

Junying Yuan

46:50

Ubiquitination regulated RIPK1 activation controls apoptosis and necroptosis

Justus Kebschull

57:56

Exploiting DNA sequencing technology for high-throughput neuroanatomy

Rudolf Jaenisch

48:25

Stem cells and epigenetic regulation in development and disease

David Page

50:23

Sex differences in health and disease

Craig Pikaard

42:29

Mechanisms of selective gene silencing

Henrich Gottlinger

1:18:07

HIV release and infectivity—From ESCRTs to SERINCs

P.Read Montague

1:03:50

Connecting mind and brain in a computational age

Lee Zou

46:18

Targeting the aberrant R-Loop accumulation in cancer cells with ATR inhibitors

Joan Brugge

Oxidative Stress Defenses in Cancer

Antonio Giraldez

Elucidating the interplay between RNA sequence, structure and translation regulation during vertebrate embryogenesis

Matthew State

56:17

Lost in translation—Moving from de novo mutations to pathophysiology

Eric Betzig

1:02:37

Imaging cellular structure and dynamics from molecules to organisms

Cedric Feschotte

Transposable elements as catalysts of cellular innovation

Josh Dubnau

Retrotransposon storm hypothesis of ALS—The dangers of a Collyer's genome

Blake Wiedenheft

Evolutionary outcomes of CRISPR-anti-CRISPR conflict

Katherine Pollard

Population genetic models for human associated microbes

Matthew Stephens

Lessons learned—Reflections on some research projects in computational biology, where they came from, and where they went

Trey Ideker

Decoding genomes using the hierarchical (network) architecture of the cell

Clare Bryant

28:25

Pattern recognition receptors and the host response to Salmonella infection

Molly Przeworski

49:59

What drives the dependence of human germline mutation rates on sex, age, and time?

Robert Waterston

A transcriptional program for the C.elegans embryo at single cell resolution-My life with worms

Bryan Cullen

1:05:16

Retroviral Epitranscriptomics

Jeremy Luban

1:12:10

The ineluctable modality of the retrovirus

Lalita Ramakrishnan

1:07:47

A zebrafish guide to susceptibility, pathogenesis and treatment

Daniel Haber

41:15

Circulating tumor cells—From vascular invasion to metastatic seeding

Tyler Jacks

Exploring tumor progression at the resolution of single cells

Jonathan Pritchard

40:16

Historically much of our intuition in genetics has come from studies of simple/single-gene traits

James Eberwine

1:02:00

Single Cell Multiomics Informs Emergent Cell Biologies

Hopi Hoekstra

53:07

A tale of tails: genetics, development and evolution

Svante Pääbo

52:27

Archaic Genomics

Dennis Burton

1:12:30

Broadly neutralizing antibodies, HIV and an AIDS vaccine

Anna Marie Skalka

Science advances and research adventures 60 years and counting…

Eileen White

Metabolic Control of Cancer Immune Tolerance

Fyodor Urnov

19:19

Tribute: Rosalind Franklin at 100

Susan Baserga

Unbiased discovery of molecules that control nucleolar function

Mauro Costa-Mattioli

32:55

The ISR in Brain Health and Disease

Richard Young

51:14

Nuclear condensates in gene regulation and disease pathology

Allan Spradling

37:33

The conserved program of germ cell formation in animals

Nicole Dubilier

42:02

Eating your microbiome: Nutritional symbioses between hydrothermal vent mussels and chemosynthetic bacteria

Stephen Friend

1:05:43

Boundaries between unknown and knowns for individual symptoms from genomics to wearables?

Sylvia Richardson

59:28

ATLASQTL & EPISPOT Two joint hierarchical approaches for detecting and interpreting hotspots in molecular QTL studies

Blake Richards

Taking inspiration from the hippocampus in AI

Panel Discussion

PANEL: Science, Society, and COVID-19

Stephen Michnick

53:49

The dimensions of gene function

Kenji Matsuura

33:29

Genomic imprinting and social evolution in termites

Susanne Foitzik

34:45

Evolutionary genomics of behaviour and life history strategies in Temnothorax ants

Philip Dormitzer

1:01:08

COVID-19 Vaccine Development

Chenghua Gu

59:17

Molecular mechanisms governing the blood-brain barrier function

Daniela Witten

59:19

Beyond sample splittg:valid inference after clustering

Cynthia Wolberger

49:26

From transcription to ubiquitin and back again

Edith Heard

49:55

Of genomes and epigenomes: Lessons from the inactive X chromosome

Michael Elowitz

52:27

Multicellular Circuit Design: Natural and Synthetic

Magdalena Zernicka Goetz

1:00:05

How do we start to become ourselves?

Pavel Tomancak

59:32

Evolution of Morphogenesis

Alice Telesnitsky

Somewhere under the curve

Bruce Stillman

1:06:02

Mechanism, regulation and evolution of DNA replication origin specification in eukaryotic cells

Xuemei Chen

Noncanonical RNA capping

Rob Jackson

Plants, ecosystems, and the global carbon cycle

Don Cleveland

47:50

Scrambling the genome in cancer—Chromothripsis and extrachromosomal DNA

Jonathan Weissman

51:04

Mapping information-rich genotype phenotype landscapes with perturb-seq

Howard Chang

41:58

Genome regulation by long noncoding RNAs

Jamie Blundell

Fitness consequences and mutation rates of mosaic chromosomal alterations in clonal hematopoiesis

Chelsea Lowther

19:59

Balanced chromosomal rearrangements offer insights into coding and noncoding genomic features associated with developmental disorders

Andrew Jones

Alignment of spatial genomics and histology data using deep Gaussian processes

Anna Cuomo

Uncovering context-specific and dynamic genetic regulation of gene expression at single-cell resolution

Judith Frydman

39:00

A vicious cycle links CAG Expansions to proteostasis collapse in Huntington's Disease

Karolin Luger

Nucleosomes for all—Histone-based DNA organization in eukaryotes, archaea, viruses and bacteria

Kathleen Burns

A feeling for the human

Adam Phillippy

The human genome is finally finished—What's next?

Kathryn Roeder

Probabilistic modeling for single-cell multimodal mosaic imputation and integration

Richard Durbin

Some thoughts on demographic inference using the pairwise sequentially Markovian coalescent

Dana Pe'er

From networks within cells to tissue level networks

Nevin Krogan

Using systems approaches to understand mechanisms of disease

David Lebwohl

Initial successes with CRISPR-based in vivo genome editing for treatment of patients with severe illness

Dritan Agalliu

Mechanisms of angiogenesis and neurovascular barrier development, breakdown and repair in the central nervous system

Ingrid Wertz

Co-opting the Ubiquitin System for Therapeutic Benefit

Erich Jarvis

Large-scale, high quality reference genome projects: a new era in biology

Susan Kaech

Metabolic control of epigenetic states that drive CD8 T cell exhaustion and anti-tumor immunity

Mitchell Lazar

Nuclear receptors, circadian rhythms, and metabolic signaling—Digging deeper

Jaquelin Dudley

Simple lessons from a complex murine retrovirus

Fyodor Urnov

A clinical CRISPR frontier—From mutation to edited subject in 3 months

Alberto Kornblihtt

Chromatin control of alternative splicing: towards a combined treatment for spinal muscular atrophy

Ling-Ling Chen

Lnc-ing RNA processing and function, and beyond

Marc Freeman

Neuronal remodeling in complex metazone

Kenneth Zaret

Overcoming chromatin barriers to change cell state

Joseph Fetcho

What matters most about Zebrafish work (to me at least)

Sean Eddy

Computational analysis of RNA structure and function

Karen Miga

Complete genomes to expand studies of genetic and epigenetic inheritance of centromeres

Lior Pachter

The systems biology of a single cell

Jonathan Weissman

33:37

Epigenome editing as a tool for basic discovery and therapeutic intervention

Karolin Luger

The double life of PARP1

Judy Lieberman

My journey in HIV research

Eric Freed

Uncovering the mysteries of HIV replication (or trying to)

Jeffrey Friedman

Obesity causes and treatments-the Beginning of the End

Andre Nussenzweig

Replication-coupled and canonical DNA double strand breaks are processed by distinct mechanisms

Benjamin Neel

A Hypoxia-induced Inflammatory Cell Death Pathway Triggered by PTP1B Inhibition (New Surprise from an Old Friend)

Anne Bertolotti

Termination of the integrated stress response—From therapeutic to molecular insights

Allan Jacobson

NMD, translation termination, and readthrough therapy—Consequences and suppression of genetic nonsense

Catherine Dulac

Molecular, neural and developmental architecture of social and sickness behavior circuits

Larry Zipursky

How cell recognition molecules regulate the assembly of the Drosophila visual system

Kristian Helin

Roles of histone methylation in transcription and development

Heng Li

The assembly of a human pangenome

Jennifer Lippincott Schwartz

How cell-cell fusion reshapes fundamental cellular features

Roy Duncan

The reovirus FAST proteins—A minimalist toolbox for cell-cell membrane fusion

Katie Pollard

Sequence-to-activity modeling

Feng Zhang

Exploration of biological diversity

Christopher Walsh

You contain multitudes---Somatic mutation in human cerebral cortex

Rasmus Nielsen

Using amcestral recombination graphs for population genetic inference

Vivek Malhotra

The pathway of unconventional protein secretion

David Bartel

RNA slicing by human AGO2

Kathleen Burns

A retrotransposon in cancer—The marker and the mutator

Cedric Feschotte

Transposable elements—From parasites to symbionts

Bali Pulendran

Systems vaccinology

Patricia Wittkopp

Arrival and survival of the fittest: genetic variation affecting gene expression

Steven McCarroll

The ticking DNA clock: Lifelongsomatic expansionof repeated DNA