CSHL Leading Stand
Title: Maintaining proteasome homeostasis
Meeting: 2017 The Ubiquitin Family
Date: 04/21/2017
1:05:20
Mechanisms of transcriptional precision in the Drosophila embryo
45:48
Larry Katz Lecture
56:50
Oligodendroglial metabolism and the support of axonal intergrity
42:37
Natural populations of Caenorhabditis and studies on apparent and cryptic phenotypic variation
1:05:26
Two decades of sonic hedgehog
1:02:12
The stabilization of cell differentiation
1:46:56
Analysis of the p53 pathway in zebrafish
Mapping genome-wide nucleosome dynamics
41:19
The success strategies of transposable elements that rapidly diversify genomes
1:09:17
40 Years in Retrovirology, a Reminiscence
54:19
Germ line retroviruses-good or bad?
1:14:49
Can HIV-1 be eradicated from the individual and the world?
1:50:48
Osteoarthritis —Understanding a common complex disease
46:09
Keynote Lecture
49:15
Programmable RNA-guided genome defense in bacteria
41:42
The dinucleotide CG as a genomic signalling module
29:58
Identification and studies of mechano-transduction channels in Drosophila
29:45
Recent studies of potassium channels and a novel family of calcium-activated anion channels and cation channels
53:28
An integrated 3D network controls a bacterial cell cycle
52:01
Synergistic targeting therapies against oncoproteins for acute myeloid leukemia
45:02
The era of the cancer epigenome: Dissecting the biological and translational implications
47:10
Causes and consequences of microRNA dysregulation in cancer
35:48
The Beery Family Journey—A sequencing success
50:10
MicroRNAs can function as ligands for TLR and regulate the interactions between cancer cells and their microenviroment
45:06
Three cautions about personalized medicine
40:36
Gut morphogenesis—From physical forces to localization of stem cells
1:02:30
Considering the digital Universe of data to better diagnose and treat patients
1:02:58
58:44
Mechanisms of protein translocation across membranes
52:49
Exocytosis in neurons—Interplay between proteins and lipids
1:11:20
T cell death and chronic inflammation: An unexpected link in HIV infection
1:08:29
HIV RNAAAAAAA
50:26
The roots of obesity—Mechanisms of lipid synthesis and storage
58:22
The Logic of Your Immune System
1:05:25
“On the rules of cortical wiring and function, with implications for understanding psychiatric disorders”
1:18:37
SCAP: Sensor of Membrane Cholesterol
1:09:37
Nanoscopy with focused light
1:01:01
Stem cells and pluripotency—Mechanisms of reprogramming and gene targeting in ES cells and mice
How systems medicine is changing healthcare
59:39
Visualizing calcium—Insights into quantal synaptic transmission and cortex glial function
47:58
Proteopedia—A scientific 'Wiki' bridging the rift between 3D structure and function of biomacromolecules
1:08:44
Super-enhancers and the control of cell identity and disease
1:06:24
New insight into the neurobiology of depression
46:40
Stories from the Supplement
33:07
My daughter's DNA and every little thing about her?
50:11
Some thoughts on ever more available sequencing
55:25
Harnessing immunity to prevent and treat HIV infection
1:01:11
Genomics of hematopoietic gene regulation
53:57
How do you get rat research support in world of GWAS and whole genome sequencing in humans?
46:02
Avian genomics a decade after the publication of the chicken genome sequence
45:56
Keynote address
1:06
Neuronal mechanism of state control in Drosophila melanogaster
48:29
Genomic Discovery: Mechanisms of Meiotic Recombination
45:31
Genomic Erosion in Symbiotic Bacteria
1:05:23
The influence of immunogenetic variation on HIV disease
47:18
Targeting CAR to Treat and Prevent Liver Cancer
1:03:28
Generating and shaping novel action repertoires
1:01:15
Membrane dynamics and virus entry—From atomic structures to single-molecule movies
57.11
CryoEM image analysis of macromolecular motor assemblies
55:00
Unveiling the long-held secrets of the 26S proteasome
Tools for studying neurons, the only important cells in the brain
47:31
Targeting cancer’s engines, not its drivers
47:28
The evolution of thymic lymphomas in P53 knock-out mice
44:15
Analysis of the role of Spt6 in controlling transcriptional accuracy in yeast
59:35
Progress and perspectives of osteoporosis treatment
1:11:39
Keynote Speaker
1:33:12
Global exchange of human genetic data for medicine and research
36:11
Truth and consequences—Reflections on ethical issues in synthetic biology
46:23
Pushing the scale of Genetic Engineering
1:12:49
The Glymphatic System
1:14:13
How biology optimizes both specificity and efficiency—Single molecule studies of ubiquitylation
54:15
Ubiquitin and Autophagy Networks
1:06:04
The application of integrative sequencing for precision medicine
1:06:19
Transcriptional regulation and metabolism: key elements in the evolution and mechanisms of social life in bees
51:07
Comparative transcriptomics reveals the modular organization of ant phenotypic traits
53:40
The influence of genes and social environment on behavior and social organization
53:45
Celebrating the ubiquitin family;diversity of cullin-RING Ubl and Ub ligation mechanisms
56:07
Mendelian randomization:Harnessing genocopy/phenocopy to identify modifiable causes of disease
50:58
From the HGP to Precision Medicine
56:25
Using mouse genetics to study host-virus interactions
The Genetic Legacy of Neanderthals
48:52
MicroRNAs in aging
Posttranscriptional regulation of mitochondrial gene expression
55:06
Regulation of proteasome function in normal and disease states
1:01:02
Retroviruses; Some Perspectives
43:41
Nucleosome compaction as a regulatory mechanism during development
1:20:25
Towards a neuron cell atlas
Interrogating the robustness of gene regulatory circuits by RACIPE
1:01:26
Gene Regulatory Networks
1:27:27
"Edgetics"
53:04
Maintaining proteasome homeostasis
52:16
Ubiquitin-like proteins:From conjugation to recognition
54:33
Junk Evolution
1:11:52
Why study integration and reverse transcription
1:04:44
Manipulating cell death—The discovery and preclinical development of Bcl-2 inhibitors
52:46
Circuit mechanisms for flexible sensorimotor processing in Drosophila
59:23
De novo lipogenesis induced by ER stress is essential for hepatic steatosis and its progression to NASH
49:51
PERSONALIZED CANCER GENOMICS: IMPACT AND IMPLICATIONS
58:12
“A protein-domain approach for the analysis of disease mutations”
1:01:34
“Post-procrustean bioinformatics”
1:13:29
"Optical tools for analyzing and repairing complex biological systems"
1:27:53
"Dissection of the regulatory trajectory for early T-cell lineage commitment"
1:06:51
"Using ancient genomes and model systems to study uniquely human phenotypes"
56:21
"3D models of the human brain—What are the ethical concerns and how should they be addressed?"
50:05
Understanding the biochemical and biophysical basis for genome organization
51:47
Structural epigenomics (precision mapping of the chromatin landscape)
46:50
Ubiquitination regulated RIPK1 activation controls apoptosis and necroptosis
57:56
Exploiting DNA sequencing technology for high-throughput neuroanatomy
48:25
Stem cells and epigenetic regulation in development and disease
50:23
Sex differences in health and disease
42:29
Mechanisms of selective gene silencing
1:18:07
HIV release and infectivity—From ESCRTs to SERINCs
1:03:50
Connecting mind and brain in a computational age
46:18
Targeting the aberrant R-Loop accumulation in cancer cells with ATR inhibitors
Oxidative Stress Defenses in Cancer
Elucidating the interplay between RNA sequence, structure and translation regulation during vertebrate embryogenesis
56:17
Lost in translation—Moving from de novo mutations to pathophysiology
1:02:37
Imaging cellular structure and dynamics from molecules to organisms
Transposable elements as catalysts of cellular innovation
Retrotransposon storm hypothesis of ALS—The dangers of a Collyer's genome
Evolutionary outcomes of CRISPR-anti-CRISPR conflict
Population genetic models for human associated microbes
Lessons learned—Reflections on some research projects in computational biology, where they came from, and where they went
Decoding genomes using the hierarchical (network) architecture of the cell
28:25
Pattern recognition receptors and the host response to Salmonella infection
49:59
What drives the dependence of human germline mutation rates on sex, age, and time?
A transcriptional program for the C.elegans embryo at single cell resolution-My life with worms
1:05:16
Retroviral Epitranscriptomics
1:12:10
The ineluctable modality of the retrovirus
1:07:47
A zebrafish guide to susceptibility, pathogenesis and treatment
41:15
Circulating tumor cells—From vascular invasion to metastatic seeding
Exploring tumor progression at the resolution of single cells
40:16
Historically much of our intuition in genetics has come from studies of simple/single-gene traits
1:02:00
Single Cell Multiomics Informs Emergent Cell Biologies
53:07
A tale of tails: genetics, development and evolution
52:27
Archaic Genomics
1:12:30
Broadly neutralizing antibodies, HIV and an AIDS vaccine
Science advances and research adventures 60 years and counting…
Metabolic Control of Cancer Immune Tolerance
19:19
Tribute: Rosalind Franklin at 100
Unbiased discovery of molecules that control nucleolar function
32:55
The ISR in Brain Health and Disease
51:14
Nuclear condensates in gene regulation and disease pathology
37:33
The conserved program of germ cell formation in animals
42:02
Eating your microbiome: Nutritional symbioses between hydrothermal vent mussels and chemosynthetic bacteria
1:05:43
Boundaries between unknown and knowns for individual symptoms from genomics to wearables?
59:28
ATLASQTL & EPISPOT Two joint hierarchical approaches for detecting and interpreting hotspots in molecular QTL studies
Taking inspiration from the hippocampus in AI
PANEL: Science, Society, and COVID-19
53:49
The dimensions of gene function
33:29
Genomic imprinting and social evolution in termites
34:45
Evolutionary genomics of behaviour and life history strategies in Temnothorax ants
1:01:08
COVID-19 Vaccine Development
59:17
Molecular mechanisms governing the blood-brain barrier function
59:19
Beyond sample splittg:valid inference after clustering
49:26
From transcription to ubiquitin and back again
49:55
Of genomes and epigenomes: Lessons from the inactive X chromosome
Multicellular Circuit Design: Natural and Synthetic
1:00:05
How do we start to become ourselves?
59:32
Evolution of Morphogenesis
Somewhere under the curve
1:06:02
Mechanism, regulation and evolution of DNA replication origin specification in eukaryotic cells
Noncanonical RNA capping
Plants, ecosystems, and the global carbon cycle
47:50
Scrambling the genome in cancer—Chromothripsis and extrachromosomal DNA
51:04
Mapping information-rich genotype phenotype landscapes with perturb-seq
41:58
Genome regulation by long noncoding RNAs
Fitness consequences and mutation rates of mosaic chromosomal alterations in clonal hematopoiesis
19:59
Balanced chromosomal rearrangements offer insights into coding and noncoding genomic features associated with developmental disorders
Alignment of spatial genomics and histology data using deep Gaussian processes
Uncovering context-specific and dynamic genetic regulation of gene expression at single-cell resolution
39:00
A vicious cycle links CAG Expansions to proteostasis collapse in Huntington's Disease
Nucleosomes for all—Histone-based DNA organization in eukaryotes, archaea, viruses and bacteria
A feeling for the human
The human genome is finally finished—What's next?
Probabilistic modeling for single-cell multimodal mosaic imputation and integration
Some thoughts on demographic inference using the pairwise sequentially Markovian coalescent
From networks within cells to tissue level networks
Using systems approaches to understand mechanisms of disease
Initial successes with CRISPR-based in vivo genome editing for treatment of patients with severe illness
Mechanisms of angiogenesis and neurovascular barrier development, breakdown and repair in the central nervous system
Co-opting the Ubiquitin System for Therapeutic Benefit
Large-scale, high quality reference genome projects: a new era in biology
Metabolic control of epigenetic states that drive CD8 T cell exhaustion and anti-tumor immunity
Nuclear receptors, circadian rhythms, and metabolic signaling—Digging deeper
Simple lessons from a complex murine retrovirus
A clinical CRISPR frontier—From mutation to edited subject in 3 months
Chromatin control of alternative splicing: towards a combined treatment for spinal muscular atrophy
Lnc-ing RNA processing and function, and beyond
Neuronal remodeling in complex metazone
Overcoming chromatin barriers to change cell state
What matters most about Zebrafish work (to me at least)
Computational analysis of RNA structure and function
Complete genomes to expand studies of genetic and epigenetic inheritance of centromeres
The systems biology of a single cell
33:37
Epigenome editing as a tool for basic discovery and therapeutic intervention
The double life of PARP1
My journey in HIV research
Uncovering the mysteries of HIV replication (or trying to)
Obesity causes and treatments-the Beginning of the End
Replication-coupled and canonical DNA double strand breaks are processed by distinct mechanisms
A Hypoxia-induced Inflammatory Cell Death Pathway Triggered by PTP1B Inhibition (New Surprise from an Old Friend)
Termination of the integrated stress response—From therapeutic to molecular insights
NMD, translation termination, and readthrough therapy—Consequences and suppression of genetic nonsense
Molecular, neural and developmental architecture of social and sickness behavior circuits
How cell recognition molecules regulate the assembly of the Drosophila visual system
Roles of histone methylation in transcription and development
The assembly of a human pangenome
How cell-cell fusion reshapes fundamental cellular features
The reovirus FAST proteins—A minimalist toolbox for cell-cell membrane fusion
Sequence-to-activity modeling
