David Page
Whitehead Institute; MIT/HHMI

Sex differences in health and disease

Rudolf Jaenisch
Whitehead Institute/MIT

Stem cells and epigenetic regulation in development and disease

Justus Kebschull
Stanford University

Exploiting DNA sequencing technology for high-throughput neuroanatomy

Junying Yuan
Harvard Medical School

Ubiquitination regulated RIPK1 activation controls apoptosis and necroptosis

Steven Henikoff
Fred Hutchinson Cancer Research Center

Structural epigenomics (precision mapping of the chromatin landscape)

Geeta Narlikar
UCSF

Understanding the biochemical and biophysical basis for genome organization

Insoo Hyun
Case Western Reserve University School of Medicine

"3D models of the human brain—What are the ethical concerns and how should they be addressed?"

Svante Paabo
Max Planck Institute for Evolutionary Anthropology

"Using ancient genomes and model systems to study uniquely human phenotypes"

Edward Boyden
Massachusetts Institute of Technology

"Optical tools for analyzing and repairing complex biological systems"

Ellen Rothenberg
California Institute of Technology

"Dissection of the regulatory trajectory for early T-cell lineage commitment"

Lior Pachter
UC Berkeley

“Post-procrustean bioinformatics”

Maricel Kann
University of Maryland

“A protein-domain approach for the analysis of disease mutations”

Elaine R. Mardis
Nationwide Children's Hospital Research Institute

PERSONALIZED CANCER GENOMICS: IMPACT AND IMPLICATIONS

Michael Karin
University of California, San Diego

De novo lipogenesis induced by ER stress is essential for hepatic steatosis and its progression to NASH

Raphael Cohn
The Rockefeller University

Circuit mechanisms for flexible sensorimotor processing in Drosophila

Craig Thompson
Memorial Sloan Kettering Cancer Center

Manipulating cell death—The discovery and preclinical development of Bcl-2 inhibitors

Stephen Hughes
National Cancer Institute

Why study integration and reverse transcription

Andrew Clark
Cornell University

Junk Evolution

Anne Bertolotti
MRC LMB

Maintaining proteasome homeostasis

Christopher Lima
Memorial Sloan Kettering Cancer Center

Ubiquitin-like proteins:From conjugation to recognition

Marc Vidal
Dana-Farber Cancer Institute/Harvard Medical School

"Edgetics"

Marian Walhout
University of Massachusetts Medical School

Gene Regulatory Networks

Mingyang Lu
Jackson Laboratory

Interrogating the robustness of gene regulatory circuits by RACIPE

Aviv Regev
Broad Institute of MIT & Harvard

Towards a neuron cell atlas

Robert Kingston
Mass General Hospital/Harvard Med School

Nucleosome compaction as a regulatory mechanism during development

Alan Rein
National Cancer Institute

Retroviruses; Some Perspectives

Alfred Goldberg
Harvard Medical School

Regulation of proteasome function in normal and disease states

James Haber
Brandeis University

How Clls Fix Their Broken Chromosomes

Thomas Kunkel
NIEHS, NIH

Generating and Repairing Mismatches During Eukaryotic DNA Replication

James Watson
Cold Spring Harbor Laboratory

Discovering the Double Helix: Going for Gold!

Eric Shoubridge
McGill University

Posttranscriptional regulation of mitochondrial gene expression

Frank Slack
Harvard Medical School

MicroRNAs in aging

Svante Paabo
Max-Planck Institute

The Genetic Legacy of Neanderthals

Susan Ross
University of Pennsylvania

Using mouse genetics to study host-virus interactions

George Davey Smith
University of Bristol

Mendelian randomization:Harnessing genocopy/phenocopy to identify modifiable causes of disease

Francis Collins
National Institutes of Health

From the HGP to Precision Medicine

Laurent Keller
University of Lausanne

The influence of genes and social environment on behavior and social organization

Arul Chinnaiyan
HHMI/University of Michigan Medical School

The application of integrative sequencing for precision medicine

Judith Korb
University of Freiburg

Comparative transcriptomics reveals the modular organization of ant phenotypic traits

Gene Robinson
University of Illinois

Transcriptional regulation and metabolism: key elements in the evolution and mechanisms of social life in bees

Ivan Dikic
Goethe University Medical School

Ubiquitin and Autophagy Networks

Brenda Schulman
St. Jude Children's Research Hospital

Celebrating the ubiquitin family;diversity of cullin-RING Ubl and Ub ligation mechanisms

Marc Kirschner
Harvard Medical School

How biology optimizes both specificity and efficiency—Single molecule studies of ubiquitylation

Maiken Nedergaard
University of Rochester Medical Center

The Glymphatic System

Christopher Voight
Massachusetts Institute of Technology

Pushing the scale of Genetic Engineering

Laurie Zoloth
Northwestern University

Truth and consequences—Reflections on ethical issues in synthetic biology

Toshio Matsumoto
University of Tokushima

Progress and perspectives of osteoporosis treatment

David Haussler
University of California, Santa Cruz Genomics Institute

Global exchange of human genetic data for medicine and research

Dana Carroll
University of Utah Medical School

Genome engineering with targetable nucleases

Fred Winston
Harvard Medical School

Analysis of the role of Spt6 in controlling transcriptional accuracy in yeast

Arnold Levine
Institute for Advanced Studies & Rutgers Cancer Institute

The evolution of thymic lymphomas in P53 knock-out mice

Gerard Evan
University of Cambridge

Targeting cancer’s engines, not its drivers

Kate Arnold
University of St. Andrews

The search for language in nonhuman primates

Tecumseh Fitch
University of Vienna

A comparative approach to the neurobiology of language

Constance Scharff
Freie Universitat Berlin

FoxPs in birds and insects

Christoph Kayser
University of Glasgow

The neural mechanisms of speech encoding: from oscillations to neural populations

Silvia Paracchini
University of St. Andrews

Dyslexia and laterality; is there a link?”

David Poeppel
New York University

How can we develop linking hypotheses between genetics, computational neuroscience, and language research?

Peter Hagoort
Max Planck Institute for Psycholinguistics

The neurobiology of language beyond the information given

Wolfgang Enard
Ludwig-Maximilians University Munich

Mice, chimpanzees and the molecular basis of speech

Simon Fisher
Max Planck Institute for Psycholinguistics

Genes, speech and language: translating the genome in human neuroscience

Liina Pylkkanen
New York University

Combinatory semantics in the cognitive neuroscience of language

Evelina Fedorenko
Massachusetts Institute of Technology

The language network and its place within the broader architecture of the human mind and brain

Matt Davis
MRC Cognition and Brain Sciences Unit

The neurobiology of spoken word recognition

Nina Dronkers
University of California, Davis

What has the study of adult aphasia taught us about language

Karen Emmorey
San Diego State University

The impact of distinct sensory-motor systems on the neurobiology of language: signed vs. spoken language

Mairead MacSweeney
University College London

The impact of deafness on the neurobiology of spoken language

Kate Watkins
Oxford University

Similarities and differences in the neural correlates of developmental disorders of speech and language

Richard Aslin
University of Rochester

Speech perception and work recognition in infants and adults

Richard Aslin
University of Rochester

Speech perception and work recognition in infants and adults Part 2

Tara McAllister Byun
New York University

Perception-production relations in speech acquisition and disorders: A view from American English

Loren Looger
Howard Hughes Medical Institute

Tools for studying neurons, the only important cells in the brain

Charles Chavkin
University of Washington

Understanding Stress as a Risk factor for Drug Addiction (part 2)

Charles Chavkin
University of Washington

Understanding Stress as a Risk factor for Drug Addiction (part 1)

Jon-Kar Zubieta
University of Michigan

Dopamine and Opioid Systems in Pain and Chronic Pain

Brigitte L. Kieffer
IGBMC Strasbourg

Opioid receptors in addiction and mood disorders; mouse genetic approaches

Chris Evans
UCLA

New Therapeutic Approaches: Agonist Directed Signaling Heterodimers Antibodies

Kelly Tan
Unversite de Geneva

Probing inhibitory Circuits of the VTA with Pharmagocolgical and Optogenetic tools

M. Imad Damaj
Virginia Institute for Psychiatric &Behavioral Genetics

Nicotine

Lex Kravitz
National institute of Diabetes and Digestive and Kidney Diseases

Optogenetic Investigations of Addiction

Cyril Herry
Neurocentre Magendie, INSERM

Identification and Manipulation of Neuronal Circuits Controlling Fear Behavior

Nora Volkow
National Institute on Drug Addiction

Fronto-Striatal Circuitry in Addiction

Jeff Dalley
University of Cambridge

Addiction-a disorder of neural and psychological transitions from impulsivity to compulsivity

David Belin
Department of Pharmacology, University of Cambridge

From recreational drug use to compulsive drug seeking habits

Markus Heilig
Laboratory of Clinical and Translational Studies, NIAAA

A translational perspective on the neurobiology and treatment of alcohol addiction

Rafael Maldonado
University Pompeu Fabra Barcelona

Involvement of CB1 Cannobinoid Receptors in addictive behavior and motor coordination.

Rainer Spanagel
Institute of Psychopharmacology University of Heidelberg, Germany

Alcohol Addiction

Andreas Zimmer
Institute of Molecular Psychiatry University of Bonn

Cannabinoid signaling and aging (Part 2)

Andreas Zimmer
Institute of Molecular Psychiatry University of Bonn

Cannabinoid signaling and aging (Part 1)

Angus Nairn
Department of Psychiatry, Yale University School of Medicine

Molecular and Cellular Mechanisms of Addictive Drugs: Signal Transduction Mechanisms

Marina Picciotto
Yale University

Nicotinic Acetylcholine Receptors and Nicotine Addiction

Tuuli Lappalainen
New York Genome Center & Columbia University, New York, NY

Integration of Transcriptome and Genome Sequencing Data in Population-Scale Data Sets

Joseph Pickrell
New York Genome Center, New York, NY

Analysis of Genetic Variation In Human Gene Regulation

Rafael Irizarry
John Hopkins Bloomberg School of Public Health, Baltimore, MD

Accounting for Cellular Heterogeneity is Critical in Epigenetic Studies

Rafael Irizarry
John Hopkins Bloomberg School of Public Health, Baltimore, MD

Batch effects, experimental design, and methylation data analysis

Rafael Irizarry
John Hopkins Bloomberg School of Public Health, Baltimore, MD

Factor Analysis

John Stamatoyannopoulos
Univ. of Washington School of Medicine, Seattle, WA

Decoding the Human Genome: Mapping and analysis of regulatory DNA

John Stamatoyannopoulos
Univ. of Washington School of Medicine, Seattle, WA

Forward Propagation of Regulatory Information During Differentiation

Joseph Pickrell
New York Genome Center, New York, NY

Detection and Interpretation of Genetic Variants that Influence Human Traits

Aedin Culhane
Harvard University School of Public Health, Boston, MA

Exploratory data analysis

Wolfgang Baumeister
Max Planck Institut for Biochemistry

Unveiling the long-held secrets of the 26S proteasome

Keiichi Namba
Osaka University

CryoEM image analysis of macromolecular motor assemblies

Stephen Harrison
Harvard Medical School

Membrane dynamics and virus entry—From atomic structures to single-molecule movies

Paul Bieniasz
Aaron Diamond AIDS Research Center

Keynote Speaker

Mary Carrington
National Cancer Institute

The influence of immunogenetic variation on HIV disease

David Moore
Baylor College of Medicine

Targeting CAR to Treat and Prevent Liver Cancer

Rui Costa
Champalimaud Neuroscience Program

Generating and shaping novel action repertoires

Peter Donnelly
Wellcome Trust Centre for Human Genetics

Genomic Discovery: Mechanisms of Meiotic Recombination

Nancy Moran
University of Texas - Austin

Genomic Erosion in Symbiotic Bacteria

Hidehiko Inagaki
HHMI Janelia Farm Research Campus

Neuronal mechanism of state control in Drosophila melanogaster

Ramon Parsons
Icahn School of Medicine at Mount Sinai

Keynote address

David Burt
Roslin Institute & R(D)SVS University of Edinburgh

Avian genomics a decade after the publication of the chicken genome sequence

Jacob Howard
Medical College of Wisconsin

How do you get rat research support in world of GWAS and whole genome sequencing in humans?

Ross Hardison
Pennsylvania State University

Genomics of hematopoietic gene regulation

Michel Nussenzweig
HHMI/Rockefeller University

Harnessing immunity to prevent and treat HIV infection

Hugh Reinhoff
Children's Hospital Oakland Research Institute

My daughter's DNA and every little thing about her?

Gholson Lyon
Cold spring Harbor Lab

Advancing precision medicine through clinical grade whole genome sequencing, return of 10 results, and deep brain stimulation

Richard Durbin
Wellcome Trust Sanger institute

Some thoughts on ever more available sequencing

Lior Pachter
UC Berkeley

Stories from the Supplement

Max Alekseyev
University of South Carolina

Reconstruction of ancestral genomes in presence of gene loss

Eric Nestler
Mount Sinai Univ

New insight into the neurobiology of depression

Richard A. Young
Whitehead Institute for Biomedical Research and Massachusetts Institute of Technology

Super-enhancers and the control of cell identity and disease

Jan Melom
Massachusetts Institute of Technology

Visualizing calcium—Insights into quantal synaptic transmission and cortex glial function

Rudolf Jaenisch
Whitehead Institute/MIT

Stem cells and pluripotency—Mechanisms of reprogramming and gene targeting in ES cells and mice

Joel Sussman
Weizmann Institute of Science, Rehovot, Israel

Proteopedia—A scientific 'Wiki' bridging the rift between 3D structure and function of biomacromolecules

Leroy Hood
Institute for Systems Biology, Seattle, Washington

How systems medicine is changing healthcare

Stefan Hell
Max Planck Institute for Biophysical Chemisty

Nanoscopy with focused light

Michael Brown
UT Southwestern Medical School

SCAP: Sensor of Membrane Cholesterol

Eric Nestler
Mount Sinai Univ

Transcriptional and Epigenetics Mechanisms of Addiction Part 2

Eric Nestler
Mount Sinai Univ

Transcriptional and Epigenetics Mechanisms of Addiction

Peter Kalivas
Medical Uiversity of South Carolina

Using Synaptic Plasticity to Cure Addiction. Part 1

Peter Kalivas
Medical Uiversity of South Carolina

Using Synaptic Plasticity to Cure Addiction. Part 2

William Yang
UCLA

Genetic Dissection of Basal Ganglia Circuitry:Novel Insights into Opiate Reward

R.Christopher Pierce
University of Pennsylvania

Forgiving the Sins of the Father: Epigenetic Inheritance of Addiction Phenotypes. Coming soon.

David Belin
INSERM

The psychobiology of incentive habits: relevance for the understanding of addictions

Brigitte Kieffer
IGBMC,France

Opioid Receptor Function in Addiction and Mood Disorders: Mouse Genetic Approaches

David Belin
INSERM

We are not equally vulnerable to addiction

Nora Volkow
National Institute on Drug Abuse National Institutes of Health

Molecular Imaging in SUD: Opportunities for Translation into Basic and Clinical Neuroscience

Angus Nairn
Yale University School of Medicine

Course Lecture Part 1

Angus Nairn
Yale University School of Medicine

Course Lecture Part 2

Antonello Bonci
National Institute on Drug Abuse NIDA

Optogenetic approaches to studying substance abuse and synaptic plasticity

Jonathan Pollock
National Institute on Drug Abuse/NIH/DHHS

Strategic Directions and Opportunities for Funding

Rajita Sinha
Yale University School of Medicine

Clinical Neurobiology of Stress and Addiction: Risk, Relapse and Treatment Development

David Goldman
NIAAA/LNG

Genetics of addiction: Alleles, mechanisms, and contexts

David Goldman
NIAAA/LNG

What is the Phenotype

Marina Picciotto
Yale University School of Medicine

Molecular Basis of Nicotine Addiction

Rob Edwards
Univ of California San Francisco

The Corelease of Glutamate with Monoamines

Charles Chavkin
Univ of Washington

Therapeutic Potential of Kappa Opiods in Pain and Addiction

Charles Chavkin
Univ of Washington

Understanding stress as a risk factor for Drug Addiction

Barbara Mason
Scripps Research Institute of La Jolla, California

Predictive Validity of Human Laboratory Models for Medication Development in Alcohol Dependence

George Koob
Scripps Research Institute of La Jolla, California

Neurobiology of Addiction: View from the Dark Side

Edmund Rolls
Oxford Centre for Computational Neuroscience and University of Warwick

“On the rules of cortical wiring and function, with implications for understanding psychiatric disorders”

Kevin Mitchell
Smurfit Institute of Genetics, Trinity College Dublin

The Miswired Brain

Steve Horvath
University of California, Los Angeles, CA

Weighted network analysis applied to Huntington's disease

Steve Horvath
University of California, Los Angeles, CA

Extended Overview of Weighted Gene Co-Expression Network Analysis (WGCNA)

Steve Horvath
University of California, Los Angeles, CA

Clustering methods used in genomics

Steve Horvath
University of California, Los Angeles, CA

Classification and Supervised Learning

Christina Leslie
Memorial Sloan-Kettering Cancer Center, New York, NY

Statistical Analysis

Sean Davis
National Institutes of Health, Bethesda, MD

Clustering

Sean Davis
National Institutes of Health, Bethesda, MD

Microarray Preprocessing

Mark Gerstein
Yale University, New Haven, CT

Statistical Methods in Functional Genomics -- or How Biology Grapples with Big Data

Nicholas Ingolia
Carnegie Institution, Baltimore, MD

Genome-wide Profiling of Translation Initiation and Protein Synthesis

Emily Hodges
Cold Spring Harbor Laboratory

Domains of DNA Hypomethylation are Pockets of Activity for Genome Regulation and Organization

Olivier Elemento
Weill Cornell Medical College

Basics of high-throughput sequencing

Olivier Elemento
Weill Cornell Medical College

Read Formats

Olivier Elemento
Weill Cornell Medical College

ChIP-seq

Naomi Altman
Penn State University

Replicability, Two objectives of Bioinformatics Experiments, From organism to data and Steps in Designing an "omics" Study

Naomi Altman
Penn State University

Statistics for Differential Expression in Microarray Studies

Naomi Altman
Penn State University

Count and Tabular Data

Naomi Altman
Penn State University

Basic Statistical Inference for Bioinformatics Studies

Naomi Altman
Penn State University

Statistics for Differential Expression in Sequencing Studies

Todd Riley
Columbia University

Biological Application: Mutations in Hox genes cause homeotic transformations during embryogenesis

Todd Riley
Columbia University

Building accurate sequence-to-affinity models from in vitro binding data using FeatureREDUCE

Harmen Bussemaker
Columbia University

Scoring overlap with GO cats

Harmen Bussemaker
Columbia University

Probing DNA shape and methylation state on a genomic scale with Dnase I

Harmen Bussemaker
Columbia University

Modeling Condition-Specific Regulation of mRNA Stability in Yeast

Harmen Bussemaker
Columbia University

Learning mechanistic models that predict expression from sequence

Harmen Bussemaker
Columbia University

Learning mechanistic models that predict expression from sequence Part 2

Hidde Ploegh
Whitehead Institute for Biomedical Research

The Logic of Your Immune System

Ben Berkhout
Academic Medical Center, University of Amsterdam

HIV RNAAAAAAA

Robert Farese
University of California, San Francisco

The roots of obesity—Mechanisms of lipid synthesis and storage

Warner Greene
Gladstone Institutes

T cell death and chronic inflammation: An unexpected link in HIV infection

Tom Rapoport
HHMI/Harvard Medical School

Mechanisms of protein translocation across membranes

Reinhard Jahn
Max Planck Institute for Biophysical Chemistry

Exocytosis in neurons—Interplay between proteins and lipids

Eric Lander
The Broad Institute of MIT & Harvard

Keynote Lecture

Eric Schadt
Mt Sinai Medical Center

Considering the digital Universe of data to better diagnose and treat patients

Clifford Tabin
Harvard Medical School

Gut morphogenesis—From physical forces to localization of stem cells

Maynard Olson
University of Washington

Three cautions about personalized medicine

Retta Beery


The Beery Family Journey—A sequencing success

Carlo Croce
Ohio State University

MicroRNAs can function as ligands for TLR and regulate the interactions between cancer cells and their microenviroment

Carlo Croce
Ohio State University

Causes and consequences of microRNA dysregulation in cancer

Stephan Baylin
Johns Hopkins University, Sidney Kimmel Comprehensive Cancer Center

The era of the cancer epigenome: Dissecting the biological and translational implications

Zhu Chen
Ministry of Health P.R. China/Shanghai Institute of Hematology

Synergistic targeting therapies against oncoproteins for acute myeloid leukemia

Lucy Shaprio
Stanford University

An integrated 3D network controls a bacterial cell cycle

Lily Jan
University of California San Francisco

Recent studies of potassium channels and a novel family of calcium-activated anion channels and cation channels

Yuh-Nung Jan
University of California San Francisco

Identification and studies of mechano-transduction channels in Drosophila

Adrian Bird
University of Edinburgh, UK

The dinucleotide CG as a genomic signalling module

Jennifer Doudna
HHMI/University of California, Berkeley

Programmable RNA-guided genome defense in bacteria

Charles Sherr
HHMI/St.Jude Children's Res. Hospital

Keynote Lecture

Stefan Lohmander
Lund University Sweden and University of Southern Denmark

Osteoarthritis —Understanding a common complex disease

John Mellors
University of Pittsburgh

Can HIV-1 be eradicated from the individual and the world?

Jonathan Stoye
MRC National Institute for Medical Research

Germ line retroviruses-good or bad?

Maxine Linial
Fred Hutchinson Cancer Research Center

40 Years in Retrovirology, a Reminiscence

Susan Wessler
University of California, Riverside

The success strategies of transposable elements that rapidly diversify genomes

Steven Henikoff
Fred Hutchinson Cancer Research Center

Mapping genome-wide nucleosome dynamics

John Gurdon
Gurdon Institute, UK

The stabilization of cell differentiation

David Lane
A*STAR, p53 Laboratory

Analysis of the p53 pathway in zebrafish

Philip Ingham
Institute of Molecular and Cell Biology

Two decades of sonic hedgehog

Marie-Anne Felix
IBENS, France

Natural populations of Caenorhabditis and studies on apparent and cryptic phenotypic variation

Weizhe Hong
Stanford University

Larry Katz Lecture

Bob Kingston
Harvard Medical School

Oligodendroglial metabolism and the support of axonal intergrity

Michael Levine
UC Berkeley

Mechanisms of transcriptional precision in the Drosophila embryo